Hand pain can be caused by disease or injury affecting any of the structures in the hand, including the bones, muscles, joints, tendons, blood vessels, or connective tissues. Hand pain is one feature of joint inflammation (arthritis) that may be felt in the hand. Rheumatoid arthritis and osteoarthritis are the two most common types of arthritis in the hand. Repetitive motion injuries, including carpal tunnel syndrome, can cause pain in the wrist and hand. Tumors of the structures in the hand are a very rare cause of hand or finger pain. Certain conditions such as diabetes can cause damage to the nerves, resulting in pain, numbness, or tingling of the arms and legs. This phenomenon, known as peripheral neuropathy, can also sometimes cause hand pain. DeQuervain’s disease is a swelling and inflammation of the tendon around the thumb, causing pain in the thumb and lower arm. Trauma or injury to any of the structures in the hand is another common cause of hand pain.